Learn aAPC
Artificial antigen presenting cells (aAPC) are cell-based or synthetic material-based three-dimensional platforms capable of activating an anti-tumor T cell response. These platforms are decorated with the necessary signals required to activate T cells and can be used to stimulate T cells against a specific tumor antigen either ex vivo followed by adoptive cell transfer or directly in vivo. Synthetic aAPC have several advantages over cell-based aAPC because of their increased shelf-life, ability to engineer specific properties, and decreased cost. Our lab focuses on utilizing various engineering technologies to improve synthetic aAPC. We use superparamagnetic materials, biodegradable polymers, and variations in signaling molecules to develop next generation aAPC.
- Target CD8 : Ben, Daniela
- Target CD4 : Si-Sim, Mara, Daniela
- TRM – Shuyi
